Figure 1. The F27S mutation in SUR1 does not alter K_ATP channel gating property. (A) Representative recordings testing MgADP responses of WT and F27S channels expressed in COSm6 cells without overnight carbamazepine treatment. (B) Quantification of the MgADP response. Currents in 0.1 mM ATP or 0.1 mM ATP plus 0.25 mM ADP were expressed as percent currents of those observed in K-INT. There is no statistical significance in MgADP response between F27S and WT channels.