Figure 1. BPA-MS (10 μM) activates BK channels in W-C patches in a β1 subunit-dependent manner. (A) Contains families of current traces from a representative cell expressing BK α subunits. The voltage template is shown below; cells were held at -80 mV and stepped from -100 to +100 mV in 20 mV increments. The addition of 10 μM BPA-MS had no effect on current in cells expressing BK α subunits alone. (B) Shows group data (n = 5) illustrating the lack of effect of 10 μM BPA-MS on BK channels composed of α only (P = 0.99 by 2RM-ANOVA). (C) Contains families of current traces from a representative cell expressing BK α + β1 subunits. BPA-MS (10 μM) increased current in cells expressing BK channels composed of α + β1 subunits. (D) Shows group data (n = 7) illustrating the increase in BK α + β1 current elicited by 10 μM BPA-MS (asterisks indicate P < 0.05 by 2RM-ANOVA with Bonferroni post test).