Figure 7. The effect of BPA-MS on NPo is rapid and reversible. (A) NPo vs. time is plotted for a single I-O patch pulled from a cell expressing BK α + β1 (symmetrical 140 mM K+; pCa 7; patch potential +40 mV). Cytoplasmic BPA-MS significantly activates BK α + β1. Washing out BPA-MS rapidly returns NPo toward baseline. (B) Shows current vs. time for a representative W-C experiment. Bath-applied BPA-MS increases current in a reversible manner. (C) Contains current traces from experiment plotted in (B).