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. 2014 Oct 20;9(10):e110231. doi: 10.1371/journal.pone.0110231

Table 1. Baseline population characteristics of all breast cancer cases diagnosed in Finland during 1995–2003.

Non-users of any cholesterol-lowering drugs Statin usersa Fibrate or resin usersa
n (%) 26,941 (86.2%) 4,151 (13.3%) 313 (1%)
Median age at diagnosis (yrs) 58 64 65
P-value Reference <0.001 <0.001
Age-groupb
> = 55 years 15,919 (59.3%) 3,383 (81.5%) 249 (79.6%)
<55 years 10,918 (40.7%) 768 (18.5%) 64 (20.4%)
P-value Reference <0.001 <0.001
Deaths; n (% of the subgroup) 5,658 (21.0%) 318 (7.6%) 50 (16.0%)
Breast cancer deaths; n (% of all deaths) 3,434 (60.7%) 166 (52.2%) 27 (54%)
Years of follow-up (median; 95% range) 3.17 (0.08–8.50) 3.83 (0.08–8.67) 3.50 (0.25–8.51)
Stage at diagnosis:
Local; n (%) 22,747 (84.8%) 3,696 (89.0%) 277 (88.5%)
Metastatic; n (%) 1,899 (7.1%) 152 (3.7%) 11 (3.5%)
Unknown 2,191 (8.2%) 303 (7.3%) 25 (8.0%)
P-value Reference <0.001 0.036
Tumor morphology:
Ductal ca 20,524 (76.2%) 3,252 (78%) 263 (84%)
Lobular ca 4,278 (15.9%) 643 (15.4%) 32 (10.2%)
Other 2,139 (7.9%) 274 (6.6%) 18 (5.8%)
P-value Reference 0·005 0.002
Treatment selection:
Any surgery; n (%) 24,908 (92.5%) 3,989 (95.7%) 297 (94.9%)
P-value Reference 0.003 NS
Any radiation therapy; n (%) 14,474 (53.7%) 2,291 (55.0%) 170 (54.3%)
Chemotherapy 6,367 (23.6%) 628 (15.1%) 51 (16.3%)
P-value Reference <0·001 0.012
Hormonal therapy 6,787 (25.2%) 849 (20.4%) 73 (23.3%)
P-value Reference <0·001 NS
Other therapy 220 (0.8%) 17 (0.4%) 1 (0.3%)
P-value Reference <0.001 NS
a

Any pre-diagnostic or post-diagnostic use.

b

Age cutoffs selected to reflect menopausal status of the majority of women at breast cancer diagnosis.