. 2014 Oct 20;9(10):e110547. doi: 10.1371/journal.pone.0110547

Table 1. Demographic and clinical profiles of patients with a Clinical Dementia Rating of 0 at baseline.

		Non-converter(N = 26)		Memory-only converter(N = 7)		Memory-plus converter(N = 6)		Differences among groups
Age at baseline (years)		62.2±5.9		67.7±5.5		71.8±2.6		Memory-plus>Non-converters^b
Gender (male/female)		12/14		2/5		1/5
Education (years)		11.8±2.5		11.1±2.5		12.0±2.8
Test-retest interval (days)		1140.2±110.7		1107.7±43.5		1109.7±59.7
Disease duration at baseline (years)		4.3±3.7		5.0±6.9		5.0±3.2
Age at onset (years)		58.0±7.3		63.6±6.0		67.2±5.4		Memory-plus>Non-converters^b
Levodopa equivalent dose at baseline (mg/day)		303.5±233.1		378.9±320.4		533.6±340.2
UPDRS part III	Baseline	18.0±7.3		18.9±8.0		16.5±6.2
	Progression rate(/years)	−0.02±2.0		−0.8±0.8		4.0±5.2		Memory-plus>Non-converters^b; Memory-plus>Memory-only^b
UPDRS tremor score ^¶	Baseline	0.5±0.4		0.4±0.6		0.3±0.4
	Third year	0.3±0.3		0.2±0.2		0.3±0.3		Main effect of non-tremor score: Memory-plus>Non-converters^b;Memory-plus>Memory-only^b
UPDRS non-tremor score ^¶	Baseline	0.7±0.3		0.7±0.4		0.7±0.2
	Third year	0.8±0.3		0.7±0.4		1.6±0.2
CDR sum of boxes	Baseline	0		0		0		NE
	Third year	0		0.5		1.8±0.8		NE
MMSE	Baseline (/30)	28.2±1.8		27.3±2.6		27.5±1.9
	Progression rate(/years)	0.1±0.6		−0.1±0.9		−0.6±0.7
ADAS word recall ^†	Baseline (/30)	19.3±3.4		17.3±4.5		17.8±4.4
	Progression rate(/years)	0.6±0.9		1.2±1.1		−0.03±1.2
Overlapping figure ^‡	Baseline (/40)	33.4±4.0		29.6±2.4		25.3±6.3		Non-converters>Memory-plus^b
	Progression rate(/years)	−0.2±1.0		0.7±0.9		−0.9±2.0
Backward digit-span ^§	Baseline	4.4±0.8		3.0±0.9		4.0±0.7		Non-converters>Memory-only^a
	Progression rate(/years)	−0.1±0.3		0.1±0.4		−0.2±0.2
# of patients below −1 SD at baseline and at third year	ADAS word recall ^†	9/26	3/26	3/7	1/7	3/6	3/6		NE
	Overlapping figure^‡	4/26	3/26	2/7	0/7	5/6	5/6		NE
	Backward digit-span^§	1/25	5/25	4/6	4/6	1/5	3/5		NE

Analysis of variance with post-hoc Tukey’s test was used for group-wise comparisons of baseline scores and progression rates except for the UPDRS tremor/non-tremor scores. Two-way analysis of variance with post-hoc Tukey’s test was used for the UPDRS tremor/non-tremor scores. Data are given as the mean±SD except for the fields with asterisks. a and b indicate p<0.05 and p<0.01, respectively.

*Data are given as (the number of patients below −1 SD)/(the number of patients who underwent the test).

^¶

The scores were calculated according to Lewis and colleagues. [5] Data were obtained from 21 non-converters, 6 memory-only converters and 5 memory-plus converters.

^†

The mean score for controls (n = 20, 65.5±4.8 years) is 21.3±3.5. [49].

^‡

The mean score for controls (n = 24, 66.1±5.3 years) is 32.9±4.4. [32].

^§

The mean score for controls (n = 20, 65.5±4.8 years) is 4.8±1.0. [49].

Abbreviations: UPDRS, Unified Parkinson's Disease Rating Scale; CDR, Clinical Dementia Rating; MMSE, Mini-Mental State Examination; ADAS, Alzheimer's Disease Assessment Scale; NE, not examined.