Table 1. Statistically significant mean gene expression differences between Aging and Development Periods (Multiple ANOVA results).
Reduced with Aging | Increased with Aging | ||||
Gene | Adjusted p-value | Fold-Difference | Gene | Adjusted p-value | Fold-Difference |
CX3CL1 | 5.07E-21 | −1.75 | GFAP | 4.33E-05 | 1.37 |
CX3CR1 | 8.00E-06 | −2.00 | TSPO | 1.87E-03 | 1.23 |
BDNF | 1.53E-05 | −1.39 | MOBP | 2.77E-03 | 1.43 |
CD68 | 1.56E-04 | −1.26 | TRAF6 | 3.41E-03 | 1.17 |
CASP1 | 1.63E-04 | −1.35 | NFKB1 | 7.76E-03 | 1.11 |
AIF1 (IBA1) | 1.63E-04 | −1.31 | TLR4 | 6.16E-02 | 1.12 |
PTGS2 (COX-2) | 1.75E-04 | −1.44 | IL1R1 | 9.70E-02 | 1.21 |
PDGFA | 1.34E-03 | −1.14 | |||
DBN1 | 1.34E-03 | −1.13 | |||
MYD88 | 1.34E-03 | −1.24 | |||
NGF | 1.34E-03 | −1.14 | |||
SYP | 2.11E-03 | −1.18 | |||
IL1B | 7.33E-03 | −1.22 | |||
BACE1 | 5.33E-02 | −1.11 |
Multiple ANOVA results, giving fold changes, showing that mean expression was significantly lower (left) or higher (right) in Aging compared with Development. A negative fold-change represents decreased expression in the Aging compared to Development group, and vice versa. Italicized p-values are nonsignificant after correction for multiple comparisons. In p-values, term E-number = ×10−number. (Development: n = 87; Aging: n = 144).