Table 1.
Characteristics of patients with HIV-negative cryptococcal meningitis in terms of seizures (n = 180)
| With seizures § | Without seizures | |||
|---|---|---|---|---|
| Early seizures | Late seizures | p value | ||
| n = 13 (%) | n = 15 (%) | n = 152 (%) | ||
| Mean age, years | 47.3 ± 17.3 | 52.1 ± 25.0 | 0.32 | 53.2 ± 17.9 |
| Sex (male/female) | 7/6 | 9/6 | 0.74 | 92/60 |
| Mean GCS on presentation | 11.5 ± 3.9 | 12.1 ± 4.4 | 0.71 | 13.1 ± 3.1 |
| Clinical features | ||||
| Fever/chills | 8 (61.5) | 13 (86.6) | 0.20 | 89 (58.5) |
| Headache | 9 (69.2) | 9 (60) | 0.71 | 69 (45.3) |
| Disturbed consciousness | 8 (61.5) | 8 (53.3) | 0.66 | 61 (40.1) |
| Visual disturbance | 2 (15.3) | 5(33.3) | 0.61 | 26 (17.1) |
| Hearing impairment | 1 (7.6) | 1 (6.6) | 1.0 | 4 (2.6) |
| Hyponatremia | 3 (23.1) | 2 (13.3) | 0.64 | 21 (13.8) |
| Outcome | ||||
| Death | 5 (38.4) | 10 (66.6) | 0.14 | 42 (27.6) |
| Mean length of hospitalization (days) | 58.0 ± 38.9 | 89.3 ± 62.6 | 0.08 | 56.9 ± 49.3 |
Abbreviations: HIV, human immuno-deficiency virus; GCS, Glasgow Coma Scale; SD, standard deviation; IQR, inter-quartile range.
Categorical data is presented as %.
§Patients with early and late seizure were compared.