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. 2014 Oct 20;2:143. doi: 10.1186/s40478-014-0143-5

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© Tobin et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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FPI-induced alterations in peripheral lymphocytes require CD74. (A) The number of viable cells in the spleens of CD74^Def mice is unchanged at 24 hours following sham surgery or FPI. (B) Similarly, the number of B Cells (B220⁺) and T cells (CD3⁺) in the spleens of CD74^Def mice are not significantly different at 24 hours after sham surgery or FPI. (C) Analysis of specific populations of T cells also revelaed no significant differences at 24 hours after sham surgery or FPI. For these experiments we used 5 sham surgery mice and 6 FPI treated mice. The symbol * indicates P < 0.05.