Table 2. BMEL cells differentiate in vivo with the same gene expression pattern as host cells.
| BMEL cells in vivo
|
Host liver cells
|
||||
|---|---|---|---|---|---|
| Markers | BMEL in vitro | Hepatocytes | Bile ducts | Hepatocytes | Bile ducts |
| HNF1α, β | + | + | + | + | + |
| HNF4α | + | + | — | + | — |
| DPPIV | ND | + | — | + | — |
| CPSI, GS | — | + | — | + | — |
| CK7, CK19 | + | — | + | — | + |
HNF1α, HNF1β, and HNF4α are liver-enriched transcription factors. DPPIV, CPSI, and GS (glutamine synthetase) are hepatocyte enzymes. CK7 and CK19 are expressed only by bile duct cells. ND, not determined.