Table 4. Association between XPG Asp1104His Genotypes and Clinical Characteristics of Colorectal Cancer.
| Asp/Asp | His/His+Asp/His | ||||
|---|---|---|---|---|---|
| Variables | n/% | n/% | Crude OR(95%CI) | Adjusted *OR(95% CI) | P |
| Controls(n = 884) | 355/40.2 | 529/59.8 | 1.00 (reference) | 1.00 (reference) | |
| Cases(n = 878) | 286/32.6 | 592/67.4 | 1.39 (1.14–1.69) | 1.40 (1.15–1.70) | <0.001 |
| Tumor site | |||||
| Colon | 144/31.4 | 315/68.6 | 1.47 (1.16–1.86) | 1.48 (1.16–1.87) | 0.001 |
| Rectum | 142/33.9 | 277/66.1 | 1.31 (1.03–1.67) | 1.32 (1.03–1.69) | 0.026 |
| Tumor grade | |||||
| Low | 22/35.5 | 40/64.5 | 1.22 (0.71–2.09) | 1.20 (0.70–2.06) | 0.507 |
| Intermediate | 216/31.9 | 461/68.1 | 1.43 (1.16–1.77) | 1.44 (1.17–1.78) | <0.001 |
| High | 48/34.5 | 91/65.5 | 1.27 (0.88–1.85) | 1.27 (0.87–1.85) | 0.216 |
| Dukes stage | |||||
| A+B | 144/31.8 | 309/68.2 | 1.44 (1.13–1.83) | 1.15 (1.14–1.84) | 0.002 |
| C+D | 142/33.4 | 283/66.6 | 1.34 (1.05–1.70) | 1.35 (1.06–1.72) | 0.017 |
*Adjusted for age, sex, smoking, and drinking status in logistic regression model.