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Evidence of instant blood-mediated inflammatory reaction in baboons transplanted intraportally with WT pig NICC. One-hour posttransplant baboon liver biopsies were stained with Martius Scarlet Blue (A, C) or H&E (E), or for αGal (B), complement C3c (D) or IgG (F). Massive clotting can be seen around the αGal-positive (B) NICC, along with leukocyte infiltration (E) and deposition of C3c (D) and IgG (F). All images ×20 magnification except C (×10). NICC, neonatal islet cell clusters.
