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. 2014 Jan 23;14(6):1300–1309. doi: 10.1111/ajt.12722

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© 2014 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of American Society of Transplant Surgeons

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Reduction in total clot formation (A and D), including both red blood cell sequestration (B and E) and fibrin deposition (C and F), in GTKO/CD55-CD59-HT NICC versus WT NICC xenografts. Quantitative computer image analysis was used to quantify the degree of thrombosis around the grafts at 1–3 h (A–C) and up to 8 h (D–F) posttransplant. Data are shown as mean ± SEM of the total percentage of the biopsy area. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. GTKO/CD55-CD59-HT, GTKO pigs expressing human CD55, CD59 and α1,2-fucosyltransferase (H-transferase, HT); NICC, neonatal islet cell clusters.