Fig. 3.

Comparison of firing rate changes and behavioral changes after systemic MK801 injection. (A) The mean area under the normalized postinjection rate histogram for type 1 neurons in each group is plotted on the left vertical axis. The area gives an indication of the total neural activity during this period. Total stereotypy score is plotted on the right vertical axis. Increases in neural activity at the two highest doses of MK801 are highly correlated with increases in stereotypy. (B) Plot of correlation between firing rate increases and stereotypy scores for individual experiments. Stereotypy scores recorded in 5-min time bins were correlated with the averaged rate histogram (5-min bins) of all type 1 neurons recorded in that same animal. There were poor correlations between behavior and firing rate for saline and MK801 at 0.01 mg/kg and 0.05 mg/kg, but high correlations at the two higher doses of MK801. Asterisks indicate significant difference compared to saline by ANOVA with the Bonferroni post hoc test (P < 0.05).