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Effect of MK801 on spontaneous alternation performance. (A) There was a differential dose-dependent effect of MK801 on percent alternation. The lowest dose of MK801 (0.01 mg/kg) improved performance, whereas higher doses (0.5 and 0.1 mg/kg) impaired performance. Asterisk indicates significant difference by ANOVA with the Bonferroni post hoc test (P < 0.05).
