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Effects of pravastatin (open triangles) and its derivative, NCX 6550 (filled triangles), or fluvastatin (open squares) and its derivative, NCX 6553 (filled squares), on cGMP formation in PC12 cells. PC12 cells were incubated with YC-1 (20 μM) in the presence or absence of test compounds for 45 min. cGMP accumulation is indicated as percent of vehicle (open circle). Values are expressed as mean ± SEM; n = 6 for each treatment group.
