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. 2014 Oct;20(4):423–446. doi: 10.5056/jnm14092

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© 2014 The Korean Society of Neurogastroenterology and Motility

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Important role of 5-hydroxytryptamine (5-HT) in colonic migrating motor complex (CMMC) generation. (A) A tension transducer was attached to the surface of the mid isolated murine colon. A spritz of 5-HT (0.1 μM) onto the serosal surface increased the frequency and amplitude of CMMCs. A larger dose of 5-HT (5 μM) blocked the CMMCs. Spritzing pure Krebs’ solution had no affect. (B) Intraluminal perfusion of Krebs’ solution (35°C) followed by the addition of a 5-HT₇ antagonist (SB 258719) reduced the amplitude of CMMCs, which were completely blocked following the further addition of a 5-HT₃ antagonist (ondansetron) to the lumen. These results suggests that neuronal 5-HT is important in CMMC generation and that both myenteric and submucosal IPANs are involved in initiating the CMMC (experiments performed by Robert Corrigan).