Table 5.
List of QTLs.
| QTL | Trait-group | Chr | Peak LRS | Mapping location (Mb) | Genotype with increased trait | Previous reports for QTL (citation) |
|---|---|---|---|---|---|---|
| 1 | Tr(C and CVS) | 1 | 13.1* | 117.4–126.3 | DBA/2 | |
| 2 | Tr(CVS) | 2 | 16.5* | 97.9–101.3 | C57BL/6 | Freezing to Context (Radcliffe et al., 2000; Parker et al., 2012); basal cort (Yang et al., 2008) |
| 3 | Tr(C and CVS) | 3 | 16.2*; | 118.8–124.6; 126.8–129.1 | DBA/2 | Freezing to Context (Owen et al., 1997) |
| 15.8* | ||||||
| 4 | Loc(C and CVS) | 4 | 16.5** | 65.5–95.7 | C57BL/6 | Context fear conditioning (Brigman et al., 2009) |
| 5 | Tr(CVS) | 5 | 13.3* | 121.8–127.4 | DBA/2 | Contextual fear conditioning (Parker et al., 2012); Time in Open sections of zero maze (Cook, 2009 unpublished in GeneNetwork); time spent in closed quadrants following restraint (Melloni, 2009 unpublished data on GeneNetwork) |
| 13a | Cxt(C) | 13 | 13.7* | 45.8–50.0 | DBA/2 | Contextual learning (Philip et al., 2010); glial count in amygdala (Mozhui et al., 2007) |
| 13b | Tr(C and CVS), Tn(C and CVS), Cxt(CVS) | 13 | 22.2*** | 78.1–97.5 | DBA/2 | Hippocampal volume (Philip et al., 2010); freezing during fear conditioning (Lassalle et al., 1994); hippocampal activation (Enoch et al., 2008) |
| 14 | Tn(C) | 14 | 17.3** | 71.0–73.5 | C57BL/6 | |
| 15 | Tr(SE) | 15 | 13.7* | 93.2–95.4 | DBA/2 | |
| 16 | Loc(SE) | 16 | 17.0** | 74.9–79.1 | C57BL/6 | |
| X | Tr(C and CVS), Tn3(C and CVS) | X | 17.0** | 56.2–68.3 | C57BL/6 | Hippocampal mossy fiber CA4/total MF (Lassalle et al., 1994) |
Trait/group abbreviations: C, control; CVS, chronic variable stress; Chr, chromosome; SE, stress-effect; Tr, freezing to training; Cxt, freezing to context; Tn, freezing to tone; and Loc, locomotion.
LRS: greatest LRS reported. Significant level:
*
suggestive,
**
significant,
***
highly significant per http://genenetwork.org.