Table 2. Reported cases of seizures related to pyridoxine deficiency in adults.

Author/s (year)	Age (Gender)	Medical history prior to seizures	Failed seizure treatment	Pyridoxine Pre (Post) pyridoxine treatment	Pyridoxine (Vitamin B6) treatment and response
Asnis DS, et al (3) (1993)	66 (F)	Oral administration of isoniazid 300 mg/day for 4 days following PPD test positive Just began peritoneal dialysis training program	-	-	Oral pyridoxine 50 mg/day: Seizure ceased within 24 hours
Schulze-Bonhage A, et al (4) (2004)	30 (F)	History of early childhood pyridoxine-dependent epileptic seizures Seizure free for 23 years with oral pyridoxine hydrochloride 100 mg per day Status epilepticus during week 14 of pregnancy	Days 1 and 2: parenteral phenytoin 750 mg/day Days 3 and 4: parenteral phenytoin 500 mg/day and phenobarbitone 450 mg/day→ continuous benzodiazepine infusion (bolus of 4 mg and subsequent infusion rate of 1 mg/h)	PLP(pyridoxal 5′-phosphate): 2.96 ng/mL* (19 ng/mL) *Normal range: 4.3–17.5 ng/mL)	Parenteral pyridoxine hydrochloride 100 mg/day for a week and oral pyridoxine 100 mg/day: Disappearance of epileptic discharges on the first EEG recording obtained 3 days after intravenous administration of pyridoxine and regained consciousness after antiepileptic drug was tapered off
Vasu and Saluja (5) (2006)	45 (F)	Isonicotinic acid hydrazide 300 mg/day for 2 months after being found to be PPD positive	Intravenous diazepam 5 mg, lorazepam 4 mg and fosphenytoin 1200 mg	-	Intravenous pyridoxine 5 g: Seizure ceased
Gerlach, et al (6) (2011)	54 (M)	Advanced alcoholic cirrhosis and encephalopathy Hepatic transplantation Intolerance of enteral nutrition	Intravenous phenytoin 1000 mg followed by intravenous phenytoin 100 mg every 8 hours and then intravenous phenyton 350mg every 24 hours	PLP: 2 mcg/L* (6 mcg/L) *Normal range: 5–50 mcg/L)	Intravenous pyridoxine 200 mg every 24 hours: Seizures ceased within 2 days Oral pyridoxine 100 mg daily: Seizure free
	59 (M)	End-stage renal disease and intermittent hemodialysis Hepatitis C Gastroesophageal reflux disease Evacuation of subdural hematoma	Intravenous fosphenyotoin 1000 mg followed by intravenous phenytoin 100 mg every 8 hours and enteral levetiracetam 250 mg every 12 hours then levetiracetam 500 mg every 12 hours via nasogastric tube Phenobarbital 600 mg x 2 then enteral phenobarbital 20 mg twice daily	PLP: 3 mcg/L* (5 mcg/L) *Normal range: 5–50 mcg/L)	Intravenous pyridoxine 100 mg twice daily: Seizures ceased following day Oral Pyridoxine 100 mg daily: Seizure free
	78 (M)	Intraventricular hemorrhage History of alcoholism	Intravenous phenytoin 1000 mg followed by intravenous phenytoin 100 mg every 8 hours	PLP: 4 mcg/L* (26 mcg/L) *Normal range: 5–50 mcg/L)	Intravenous pyridoxine 100mg every 12 hours: Seizures ceased within 24 hours Oral Pyridoxine 100 mg daily: Seizure free
Skodda and Müller (7) (2013)	74 (F)	Parkinson's disease treated with Levodopa/carbidopa intestinal gel infusion for 3 month Cachectic (BMI = 15.8)	Levetiracetam (500 mg/day) and lorazepam (2 mg/day) Intravenous lorazepam 0.5–1.0 mg Levetiracetam (maximum daily dose of 4000 mg) successively supplemented by lorazepam (maximum daily dose of 4 mg) and phenytoin (from 1500 mg/day to 400 mg/day)	Pyridoxine: 2.7 µg/l* (23.3 µg/L) *Normal range: 5–30 µg/L)	Pyridoxine 100 mg twice daily: Seizures ceased within 2 days
Tong (current)	79 (F)	Stage 4 chronic renal disease Weight loss (from 33 kg to 28 kg in 5 weeks) due to anepithymia following a fall and pelvic fracture	Oral clonazepam 0.25 mg – 0.75 mg/daily	-	Oral pyridoxine 50 mg for 24 hours and then 30 mg daily: seizures ceased within 24 hours and remained seizure free since