Comparison 2. Failure to respond (1‐4 weeks).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Citalopram versus TCAs	4	751	Odds Ratio (M‐H, Random, 95% CI)	0.95 [0.46, 1.98]
1.1 versus Amitriptyline	3	476	Odds Ratio (M‐H, Random, 95% CI)	1.33 [0.76, 2.31]
1.2 versus Imipramine	1	275	Odds Ratio (M‐H, Random, 95% CI)	0.45 [0.24, 0.86]
2 Citalopram versus other SSRIs	4		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Versus Escitalopram	1	143	Odds Ratio (M‐H, Random, 95% CI)	1.46 [0.75, 2.82]
2.2 Versus Fluoxetine	2	416	Odds Ratio (M‐H, Random, 95% CI)	0.89 [0.34, 2.34]
2.3 Versus Sertraline	2	245	Odds Ratio (M‐H, Random, 95% CI)	1.14 [0.60, 2.15]
3 Citalopram versus other conventional antidepressants	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 versus Reboxetine	2	458	Odds Ratio (M‐H, Random, 95% CI)	0.87 [0.27, 2.75]