Comparison 3. Failure to respond (16‐24 weeks).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Citalopram versus TCAs	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 versus Imipramine	1	472	Odds Ratio (M‐H, Random, 95% CI)	1.09 [0.69, 1.72]
2 Citalopram versus other SSRIs	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Versus Escitalopram	1	357	Odds Ratio (M‐H, Random, 95% CI)	1.04 [0.64, 1.68]
2.2 Versus Sertraline	1	400	Odds Ratio (M‐H, Random, 95% CI)	0.72 [0.45, 1.17]
3 Citalopram versus SNRIs	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Versus Venlafaxine XR	1	151	Odds Ratio (M‐H, Random, 95% CI)	0.89 [0.44, 1.82]
4 Citalopram versus other conventional antidepressants	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 versus Reboxetine	1	357	Odds Ratio (M‐H, Random, 95% CI)	0.46 [0.30, 0.70]