Comparison 8. Standardised mean difference at endpoint (6‐12 weeks).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Citalopram versus TCAs	5	402	Std. Mean Difference (IV, Random, 95% CI)	0.06 [‐0.15, 0.26]
1.1 versus Amitriptyline	1	44	Std. Mean Difference (IV, Random, 95% CI)	‐0.07 [‐0.66, 0.53]
1.2 versus Imipramine	2	289	Std. Mean Difference (IV, Random, 95% CI)	‐0.03 [‐0.27, 0.22]
1.3 versus Nortriptyline	2	69	Std. Mean Difference (IV, Random, 95% CI)	0.46 [‐0.02, 0.94]
2 Citalopram versus heterocyclics	2	131	Std. Mean Difference (IV, Random, 95% CI)	‐0.18 [‐0.65, 0.29]
2.1 versus Maprotiline	1	73	Std. Mean Difference (IV, Random, 95% CI)	0.04 [‐0.42, 0.50]
2.2 versus Mianserin	1	58	Std. Mean Difference (IV, Random, 95% CI)	‐0.44 [‐0.96, 0.09]
3 Citalopram versus other SSRIs	16	3610	Std. Mean Difference (IV, Random, 95% CI)	‐0.00 [‐0.11, 0.10]
3.1 versus Escitalopram	7	1872	Std. Mean Difference (IV, Random, 95% CI)	0.16 [0.05, 0.27]
3.2 versus Fluoxetine	3	672	Std. Mean Difference (IV, Random, 95% CI)	‐0.17 [‐0.46, 0.11]
3.3 versus Fluvoxamine	1	162	Std. Mean Difference (IV, Random, 95% CI)	‐0.19 [‐0.50, 0.12]
3.4 versus Paroxetine	1	201	Std. Mean Difference (IV, Random, 95% CI)	‐0.11 [‐0.39, 0.16]
3.5 versus Sertraline	4	703	Std. Mean Difference (IV, Random, 95% CI)	‐0.13 [‐0.31, 0.04]
4 Citalopram versus SNRIs	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
4.1 versus Venlafaxine XR	1	148	Mean Difference (IV, Random, 95% CI)	‐0.5 [‐2.93, 1.93]
5 Citalopram versus MAOIs or newer ADs	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
5.1 versus Moclobemide	1	40	Mean Difference (IV, Random, 95% CI)	‐4.6 [‐8.28, ‐0.92]
6 Citalopram versus other conventional ADs	3		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
6.1 versus Mirtazapine	1	269	Std. Mean Difference (IV, Random, 95% CI)	‐0.02 [‐0.26, 0.22]
6.2 versus Reboxetine	2	866	Std. Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.33, 0.04]