Hosak 1999.

Methods	Four‐week, randomised and open study.
Participants	Hospitalised patients. Diagnoses for inclusion (according to the ICD‐10 criteria) were: bipolar affective disorder, most recent episode depressed (8 participants); major depressive episode, single (44 participants), major depressive episode, recurrent (38 participants). Average age: 44.5 years (SD14.3).
Interventions	Citalopram: 29 participants. Amitriptyline: 31 participants. Fluoxetine: 30 participants. Citalopram dose range: 20‐60 mg/day Amitriptyline dose range: 150‐300 mg/day Fluoxetine: 20‐60 mg/day
Outcomes	Primary Outcome: mean change on Hamilton Depression Rating Scale 21‐item (HDRS‐21).
Notes	Study report published only in Czech.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "the subjects were randomized to the study antidepressant using computer randomization program (Excel) at the beginning of the initial hospitalization at the Dpt. of Psychiatry in Hradec Kralovc."
Allocation concealment (selection bias)	Unclear risk	No information reported.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	No information reported.
Incomplete outcome data (attrition bias) All outcomes	High risk	No information reported.
Selective reporting (reporting bias)	Unclear risk	No information reported.
Other bias	Unclear risk	No information reported.