Hosak 1999.
Methods | Four‐week, randomised and open study. | |
Participants | Hospitalised patients. Diagnoses for inclusion (according to the ICD‐10 criteria) were: bipolar affective disorder, most recent episode depressed (8 participants); major depressive episode, single (44 participants), major depressive episode, recurrent (38 participants). Average age: 44.5 years (SD14.3). |
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Interventions | Citalopram: 29 participants. Amitriptyline: 31 participants. Fluoxetine: 30 participants. Citalopram dose range: 20‐60 mg/day Amitriptyline dose range: 150‐300 mg/day Fluoxetine: 20‐60 mg/day |
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Outcomes | Primary Outcome: mean change on Hamilton Depression Rating Scale 21‐item (HDRS‐21). | |
Notes | Study report published only in Czech. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Quote: "the subjects were randomized to the study antidepressant using computer randomization program (Excel) at the beginning of the initial hospitalization at the Dpt. of Psychiatry in Hradec Kralovc." |
Allocation concealment (selection bias) | Unclear risk | No information reported. |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | No information reported. |
Incomplete outcome data (attrition bias) All outcomes | High risk | No information reported. |
Selective reporting (reporting bias) | Unclear risk | No information reported. |
Other bias | Unclear risk | No information reported. |