Shaw 1986.
Methods | Six‐week, double‐blind, randomised study. | |
Participants | In‐ and out‐patients who met the DSM‐III criteria for Major Depressive illness, scored 18 or more on the 17‐item Hamilton Depression Rating Scale Scale (HDRS). All participants entered into the trial within 36 hours of admission (48 hours at week end). Age range: 18‐70 years. |
|
Interventions | Citalopram: 29 participants. Amitriptyline: 30 participants. Citalopram dose range: 30‐60 mg/day. Amitriptyline dose range: 112.5‐225 mg/day. |
|
Outcomes | Outcomes: mean change on HDRS and Montgomery‐Asberg Depression Rating Scale (MADRS), Newcastle Scale, Leeds Self‐rating Depression Scale. | |
Notes | The study was funded by Lundbeck (citalopram manufacturer). | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Quote: "the trial was randomized in blocks of four". |
Allocation concealment (selection bias) | Unclear risk | No reliable information reported. |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Quote: "double blind". |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | No reliable information reported. |
Selective reporting (reporting bias) | Unclear risk | No reliable information reported. |
Other bias | Unclear risk | Sponsorship bias cannot be ruled out. |