Shaw 1986.

Methods	Six‐week, double‐blind, randomised study.
Participants	In‐ and out‐patients who met the DSM‐III criteria for Major Depressive illness, scored 18 or more on the 17‐item Hamilton Depression Rating Scale Scale (HDRS). All participants entered into the trial within 36 hours of admission (48 hours at week end). Age range: 18‐70 years.
Interventions	Citalopram: 29 participants. Amitriptyline: 30 participants. Citalopram dose range: 30‐60 mg/day. Amitriptyline dose range: 112.5‐225 mg/day.
Outcomes	Outcomes: mean change on HDRS and Montgomery‐Asberg Depression Rating Scale (MADRS), Newcastle Scale, Leeds Self‐rating Depression Scale.
Notes	The study was funded by Lundbeck (citalopram manufacturer).
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "the trial was randomized in blocks of four".
Allocation concealment (selection bias)	Unclear risk	No reliable information reported.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Quote: "double blind".
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No reliable information reported.
Selective reporting (reporting bias)	Unclear risk	No reliable information reported.
Other bias	Unclear risk	Sponsorship bias cannot be ruled out.