Study	Reason for exclusion
Adli 2008	Wrong design (non‐randomised).
Altamura 2008	Wrong intervention.
Altamura 2008b	Wrong intervention.
Amiaz 2008	Wrong diagnosis.
Amsterdam 2006	Wrong design (non‐randomised).
Amsterdam 2008	Medical/psychiatric comorbidity.
Anderer 2002	Wrong comparison.
Andersen 1993	Post‐stroke depression.
Angermann 2007	Depressed heart failure patients.
Anon 1995	Not compared with other antidepressive agents.
Anonymous 2011	Wrong design (not randomised).
Azorin 2004	This study pooled from three different clinical trials.
Baldwin 2006	Duplicate publication.
Barone 2011	Medical/psychiatric comorbidity.
Bauer 2010	Wrong comparison.
Baumann 1998a	Not compared with other antidepressive agents.
Baumann 1998b	Not compared with other antidepressive agents.
Benkelfat 1987	Only two patients randomised to citalopram.
Berney 2008	Not compared with other antidepressive agents.
Bersani 1997	Not compared with other antidepressive agents.
Beving 1985	Non‐randomised study.
Bhagwagar 2004	Patients with a previous history of depression.
Bigos 2008	Wrong population.
Bijl 2004	Wrong comparison (Escitalopram for depression).
Bjerkenstedt 1985	Not compared with other antidepressive agents.
Blier 2006	Patients randomised to various treatment strategies, including augmentation strategies and psychotherapy (STAR*D study).
Bouchard 1997	Wrong formulation of intervention (e.v.).
Boulenger 2010	Wrong comparison.
Bowden 1998	Wrong diagnosis (bipolar patients were included).
Brown 2004	Not compared with other antidepressive agents.
Bryan 2007	Association of diabetes mellitus with response to depression treatment.
Bun'kova KM	Wrong comparison.
Carman 2002	Patients with major depression or bipolar disorder.
Chakravarti 2002	Wrong design.
Chan 2009	Medical comorbidity.
Chen 2005	Post‐stroke depression.
Conte 1997	Not compared with other antidepressive agents.
Cooper‐Kazaz 2011	Double publication of Stahl 2000.
Court 2010	Wrong diagnosis.
Culang 2009	Wrong comparison.
Daly 2011	Wrong design (not randomised).
Davis 2006	Patients randomizsd to various treatment strategies, including augmentation strategies and psychotherapy (STAR*D study).
Davis 2010	Wrong comparison.
Davis 2010b	Wrong design (non‐randomised).
Deakin 2002	Not compared with other antidepressive agents.
DeBattista 2011	Wrong comparison.
Dell'Agnello 2001	Medical/psychiatric comorbidity.
Dell'Osso 2008	Wrong comparison.
Deng 2006	Wrong comparison (citalopram combined with quetiapine).
Denko 2007	Patients randomized to various treatment strategies, including augmentation strategies and psychotherapy (STAR*D study).
Devos 2008	Medical/psychiatric comorbidity.
Di Simplicio 2010	Wrong design (non‐randomised).
Diniz 2010	Wrong diagnosis.
Doggrell 2006	Wrong diagnosis (resistant depression).
Domelas 2007	Patients with coronary artery disease.
Doree 2007	Quetiapine augmentation for treatment resistant depression.
Dougherty 2009	Wrong diagnosis.
Dozois 2009	Wrong comparison.
Dunbar 2010	Wrong comparison.
Eriksson 1996	Wrong diagnosis.
Eyding 2010	systematic review and meta‐analysis (citalopram studies already included in the present review).
Fava 2006	Patients randomised to various treatment strategies, including augmentation strategies and psychotherapy (STAR*D study).
Feighner 1997	Not compared with other antidepressive agents.
Feighner 1997b	Wrong comparison.
Feighner 1999	Not compared with other antidepressive agents.
Fernandez 2005	Double reference.
Fernandez 2009	Medical/psychiatric comorbidity.
Flicker 1998	Patients with or without dementia.
Ford 2010	Wrong comparison.
Fraguas 2009	Medical/psychiatric comorbidity.
Frank 2004	Wrong design.
Garriock 2010	Wrong design (non‐randomised).
Gilbert 2008	Wrong design (non‐randomised).
Gilmer 2008	Wrong design (non‐randomised).
Glod 2004	Patients are adolescents.
Goder 2011	Wrong design (not randomised).
Gommol 2010	Wrong comparison.
Gonsai 2000	Wrong population.
Gorman 2002a	Wrong design.
Gorwood 2007	Escitalopram for preventing relapse.
Guelfi 1998	Not compared with other antidepressive agents.
Hannestad 2011	Wrong comparison.
Harrington 2002	Not compared with other antidepressive agents.
Hegerl 2005	Non randomised design.
Hellerstein 2010	Wrong comparison.
Hemels 2004	Economic evaluation.
Herrera‐Guzman 2009	Wrong comparison.
Hflich 2011	Wrong design.
Hindmarch 2000	Discontinuation treatment.
Hochstrasser 2001	Maintenance therapy.
Holtzheimer 2008	Wrong comparison.
Howland 2011	Wrong design.
Huezo‐Diaz 2009	Wrong comparison.
Johnson 2002	Wrong design.
Judge 2000	Non randomised design.
Kapitany 1999	Not compared with other antidepressive agents.
Kasckow 2010	Wrong diagnosis.
Kasper 2009	Wrong comparison.
Ketter 2006	Wrong diagnosis.
Khazaie 2006	Not randomised design.
Khazaie 2011	Medical comorbidity.
Kiosses 2010	Wrong intervention.
Klysner 2000	Not compared with other antidepressive agents.
Kornstein 2006	Escitalopram for relapse prevention.
Kovacs 1998	Not compared with other antidepressive agents.
Kraus 2008	Medical/psychiatric comorbidity.
Kroenke 2009	Medical/psychiatric comorbidity.
Kuhn 2003	Medical comorbidity.
Kupfer 2000	Double reference.
Lakey 2008	Non major depression.
Lam 2008	Wrong comparison.
Lavretsky 2010	Wrong comparison.
Leuchter 2009	Wrong comparison.
Li WQ 2006	Vascular depression.
Lindsley 2010	Wrong comparison.
Linnet 1996	Wrong design.
Liu 2006b	Medical/psychiatric comorbidity.
Liu 2006c	Medical/psychiatric comorbidity.
Llacer 2007	Depressed patients with anxiety and insomnia.
Lydiatt 2006	Wrong population.
Maas 2010	Wrong comparison.
Maksinczyk 1997	Bipolar depression.
Malik 2002	Treatment for depression as risk factor for ischemic heart disease.
Mannu 2009	Wrong comparison.
Martinez 2012	Wrong design.
Martini 2007	Not compared with other antidepressive agents.
Martiny 2004	Not compared with other antidepressive agents.
Martire 2008	Wrong population.
McCabe 2010	Wrong population (healthy people).
Mcgrath 2008	Wrong design (non‐randomised).
Mendels 1990	Not compared with other antidepressive agents.
Meyer 2001	Not randomised design.
Miao 2004	Post‐stroke depression.
Minelli 2010	Wrong comparison.
Miskowiak 2009	Wrong comparison.
Moltzen 2005	Wrong comparison.
Morasco 2010	Medical/psychiatric comorbidity.
Moretti 2002	Depression and Alzheimer’s disease.
Muhonen 2008	Medical/psychiatric comorbidity.
NCT00048815	Wrong diagnosis.
Nierenberg 2004	Minor depression.
Nowak 2003	Zinc supplementation on antidepressant therapy.
Nunez 1999	Not compared with other antidepressive agents.
Nurnberg 2008	Wrong comparison.
Nyth 1990	Not compared with other antidepressive agents.
Oberpichler‐Schwenk 2000	Wrong design.
Pae 2011	Wrong comparison.
Palmer 2002	Not compared with other antidepressive agents.
Papakostas 2000	Not compared with other antidepressive agents.
Parvin 2011	Wrong intervention.
Perlis 2009	Wrong comparison.
Petersen 1998	Double reference.
Pogosova 2004	Not compared with other antidepressants.
Portella 2010	Wrong comparison.
Prasko 2003	Cognitive behavioural therapy (short or long term) combined with pharmacotherapy.
Quante 2010	Wrong comparison.
Raisi 2007	Combination of citalopram and nortriptyline.
Rampello 2004	Wrong population.
Rampello 2004a	Citalopram alone or in combination with amitriptyline; patients with different diagnosis in comorbidity.
Rampello 2004b	Post‐stroke depression.
Rampello 2006	Treatment for panic attack.
Rapaport 2010	Wrong comparison.
Rapaport 2011	Wrong diagnosis.
Rapoport 2010	Wrong comparison.
Raskin 2011	Wrong population.
Rasmussen 1992	Not compared with other antidepressive agents.
Riva 2006	Evaluation of integrated pharmacologic and psychotherapeutic treatment.
Robinson 2008	Post‐stroke depression.
Robinson 2009	Wrong population.
Rocca 2005	Non major depression.
Roose 2004	Not compared with other antidepressants.
Rosenthal 2002	Wrong comparison.
Rush 2008	Wrong comparison.
Salloway 2002	Not compared with other antidepressants.
Schaefer 2008	Medical/psychiatric comorbidity.
Schfer 2010	Medical/psychiatric comorbidity.
Schmitt 2006	Escitalopram as continuation treatment of intravenous citalopram.
Segal 2010	Wrong population.
Serfaty 2010	Wrong comparison.
Sharp 2010	Wrong comparison.
Smith 2011	Wrong intervention.
Sneed 2007	Wrong comparison.
Soares 2006	Peri and post menopausal women.
Soares 2010	Wrong comparison.
Souery 2010	Wrong population.
Stein 2001	Wrong diagnosis.
Stein 2005	Psychotherapy plus pharmacotherapy for drug users.
Sun 2004	Refractory depression.
Swartz 2008	Wrong comparison.
Talati 2007	Patients randomised to various treatment strategies, including augmentation strategies and psychotherapy (STAR*D study).
Targacept 2008	Wrong design and wrong intervention.
Thase 2010	Pooled‐analysis (citalopram studies already included in the present review)
Thase 2011	Wrong design.
Thorell 1999	Seasonal affective disorder.
Uher 2010	Wrong comparison.
Van Bemmel 1993	Not compared with other antidepressants.
Voirol 1999	Wrong design (non‐randomised).
Wade 2000	Not compared with other antidepressants.
Wade 2006	Wrong intervention.
Wagner 2002	Patients are children and adolescents.
Wang 2005	Diagnosis is “depression induced by Alzheimer”.
Warden 2009	Wrong intervention.
Wermuth 1998	Parkinson’s disease; not compared with other antidepressants.
Wise 2011	Wrong population.
Wisniewski 2009	Wrong intervention.
Wu 2008	Wrong design (non‐randomised).
Yang 2005	Refractory depression.
Yang 2010	Wrong intervention.
Zhao 2005	Post stroke depression.
Zimbroff 2004	Citalopram for non responders depressive‐patients.
Zisook 2007	Patients with schizophrenia.
Zisook 2010	Wrong diagnosis.
Zou 2005	Citalopram combined with psychological morning exercise.