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. 2012 Jul 11;2012(7):CD006534. doi: 10.1002/14651858.CD006534.pub2

Akimova 2010.

Methods Double‐blind, randomised, longitudinal PET study using radioligand [11C]DASB
Participants 18 patients
Interventions 10 mg/d escitalopram or 20 mg/d citalopram, i.e. equal doses of the enantiomer S‐Citalopram
Outcomes Serotonin transporter availability in the unmedicated state and SERT occupancy after a single‐dose and later after the first 3 weeks of treatment with SSRIs. The Hamilton Depression Rating scale (HAM‐D, 17 items) was assessed at the screening visit and before each PET scan.
Notes Radioligand [11C]DASB is a new, highly selective PET radiotracer that shows a high affinity for serotonin transporter