Akimova 2010.
Methods | Double‐blind, randomised, longitudinal PET study using radioligand [11C]DASB |
Participants | 18 patients |
Interventions | 10 mg/d escitalopram or 20 mg/d citalopram, i.e. equal doses of the enantiomer S‐Citalopram |
Outcomes | Serotonin transporter availability in the unmedicated state and SERT occupancy after a single‐dose and later after the first 3 weeks of treatment with SSRIs. The Hamilton Depression Rating scale (HAM‐D, 17 items) was assessed at the screening visit and before each PET scan. |
Notes | Radioligand [11C]DASB is a new, highly selective PET radiotracer that shows a high affinity for serotonin transporter |