NCT00269334.

Methods	Randomised, open‐label study.
Participants	Self‐identified as of Taiwanese ethnic background, and report that both of their parents and all four of their grandparents are members of the same ethnic group; non‐responders: have a 21‐item HDRS score of > 17; partial responders: have a 21‐item HDRS score between 8 and 15; responders: have a 21‐item HDRS score of < 7. Only the non‐responder group will be included in Study II. male or female, who, if of child‐bearing potential, agrees to use effective contraception including the regular use of contraceptive pills, intra‐uterine devises or abstinence; age > 18; capable of giving informed consent.
Interventions	Citalopram Paroxetine
Outcomes	Structured Clinical Interview for DSM‐IV Disorders (SCID) at week baseline. Hamilton Depression Rating Scale (HDRS) at week 1,2,4,6,8. Beck Depression Inventory (BDI) at week 1,2,4,6,8. Clinical Global Impression Scale (CGI) at week 1,2,4,6,8. Patient's Global Improvement Scale (PGI) at week 1,2,4,6,8. Treatment Emergent Symptoms Scale (TESS) at week 1,2,4,6,8. Arizona Sexual Experience Scale (ASEX) at week 1,2,4,6,8.
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