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. 2001 Dec 15;21(24):9930–9943. doi: 10.1523/JNEUROSCI.21-24-09930.2001

Fig. 1.

Fig. 1.

Different methods of CREB antisense delivery produce different extents of CREB knockdown in the striatum. The effects of single oligonucleotide injections are shown inA–D, whereas those produced by a 14 d oligonucleotide infusion are shown inE–H. The number of CREB-immunoreactive cells in the region flanking the injection cannula is shown inA (single injection) or E (continuous infusion), and the corresponding photomicrographs are shown inA′ or E′ (antisense group), andA" or E" (control oligonucleotide). NeuN-immunoreactive neurons within the same regions are shown inB–B" andF–F". Camera lucida drawings illustrate the regional distribution of CREB knockdown after single oligonucleotide injection (C, antisense;D, control) or continuous oligonucleotide infusion (G, antisense; H, control).#p < 0.01; n ≥ 7 in all groups; values give means + SEM. Asterisks inA′, A", B′,B", E′, E", F′, andF" mark the cannula track. AS, CREB antisense;Ctrl, control oligo. Scale bars in B" andF", 200 μm.