Skip to main content
. 2001 Dec 15;21(24):9930–9943. doi: 10.1523/JNEUROSCI.21-24-09930.2001

Fig. 5.

Fig. 5.

Cocaine-induced expression of c-Fos, FosB/ΔFosB, and PDyn mRNA is dependent on CREB. Acute treatment with cocaine produced a dose-dependent increase in the number of c-Fos (A) and FosB/ΔFosB immunoreactive cells (B), and in the levels of PDyn mRNA (C), as measured on the cross-sectional area of the caudate–putamen at mid-rostrocaudal levels. Knockdown of CREB prevented the cocaine-stimulated increase in c-Fos (D), FosB/ΔFosB (E), and PDyn mRNA (F). CREB antisense-treated animals are marked as AS + and represented using bars withdiagonal stripes, whereas animals receiving control oligonucleotides are marked as AS − and represented usingbars with no texture. The data presented here are derived from two sets of experiments. Animals injected with 15 mg/kg cocaine received a single intrastriatal injection of CREB AS, whereas animals injected with 30 mg/kg cocaine or saline received a 14 d intrastriatal oligonucleotide infusion. *p < 0.05 versus saline; §p < 0.01 versus 15 mg/kg cocaine; #p < 0.05 versus control oligo; n ≥ 5 in each group; values give means + SEM.