Table 1.
Treatment groups and number of animals
| Drug dose | Oligonucleotide | Number of animals | |
|---|---|---|---|
| 6-OHDA-lesioned rats | |||
| Saline | No | 20 | |
| Acutel-DOPA | 3 mg/kg | No | 3 |
| Acutel-DOPA | 5 mg/kg | No | 5 |
| Acutel-DOPA | 5 mg/kg | CREB AS | 5 |
| Acutel-DOPA | 5 mg/kg | Control oligo | 5 |
| Acutel-DOPA | 8 mg/kg | No | 17 |
| Acutel-DOPA | 8 mg/kg | CREB AS | 16 |
| Acutel-DOPA | 8 mg/kg | Control oligo | 16 |
| Chronicl-DOPA | 8 mg·kg−1·d−1 | No | 9 |
| Chronicl-DOPA | 8 mg·kg−1·d−1 | CREB AS | 9 |
| Chronicl-DOPA | 8 mg·kg−1·d−1 | Control oligo | 9 |
| Intact rats | |||
| Saline | No | 15 | |
| Saline | CREB AS | 7 | |
| Saline | Control oligo | 6 | |
| Acute cocaine | 15 mg/kg | No | 7 |
| Acute cocaine | 15 mg/kg | CREB AS | 19 |
| Acute cocaine | 15 mg/kg | Control oligo | 19 |
| Acute cocaine | 30 mg/kg | No | 5 |
| Acute cocaine | 30 mg/kg | CREB AS | 6 |
| Acute cocaine | 30 mg/kg | Control oligo | 8 |
| Chronic cocaine | 30 mg·kg−1·d−1 | No | 5 |