Table 1.
HLA-A29:02 and newly associated loci identified in this study
| Region | Dutch cohort |
Spanish cohort |
Mega-analysis | British cohort (replication) | Meta-analysis | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele | Case MAF | Control MAF | OR (95% CI) | P | Case MAF | Control MAF | OR (95% CI) | P | OR (95% CI) | P | Case MAF | Control MAF | OR (95% CI) | P | OR (95% CI) | P | |
| HLA | HLA-A29:02 | 0.422 | 0.026 | 303.0 (124.4, 845.6) | 2.0 × 10−63 | 0.548 | 0.084 | 25.4 (8.9, 94.9) | 9.3 × 10−12 | 157.5 (91.6, 272.6) | 6.6 × 10−74 | ||||||
| ERAP2-LNPEP | rs7705093-T | 0.618 | 0.405 | 2.6 (1.8, 3.7) | 2.7 × 10−7 | 0.554 | 0.399 | 2.0 (1.0, 3.7) | 3.8 × 10−2 | 2.3 (1.7, 3.1) | 8.6 × 10−8 | 0.621 | 0.442 | 2.0 (1.1, 3.6) | 0.011 | 2.2 (1.7–2.9) | 1.7 × 10−9 |
| TECPR2 | rs150571175-A | 0.075 | 0.017 | 5.9 (2.5, 14.2) | 6.4 × 10−5 | 0.183 | 0.041 | 6.0 (2.2, 16.5) | 6.0 × 10−4 | 6.1 (3.2, 11.7) | 3.2 × 10−8 | 0.033* | 0.036* | 1.0 (0.2–1.4)* | 1* | 4.6 (2.6–8.3)* | 1.6 × 10−7* |
*This SNP failed genotyping by Sanger sequencing, so replication genotyping for this locus was at rs7159505, which had r2 = 0.83 as calculated from Go NL.