Table 1.
BCAC studies contributing cases and controls to COGS
| Study | Country | Controls | Cases | ER+ | ER− |
|---|---|---|---|---|---|
| European women | |||||
| Australian Breast Cancer Family Studya (ABCFS) | Australia | 551 | 790 | 456 | 261 |
| Amsterdam Breast Cancer Study (ABCS) | Netherlands | 1429 | 1325 | 420 | 153 |
| Bavarian Breast Cancer Cases and Controls (BBCC) | Germany | 458 | 564 | 460 | 83 |
| British Breast Cancer Study (BBCS) | UK | 1397 | 1554 | 507 | 114 |
| Breast Cancer In Galway Genetic Study (BIGGS) | Ireland | 719 | 836 | 495 | 154 |
| Breast Cancer Study of the University Clinic Heidelberg (BSUCH) | Germany | 954 | 852 | 499 | 154 |
| CECILE Breast Cancer Study (CECILE) | France | 999 | 1019 | 797 | 144 |
| Copenhagen General Population Study (CGPS) | Denmark | 4086 | 2901 | 1919 | 357 |
| Spanish National Cancer Research Centre Breast Cancer Study (CNIO-BCS) | Spain | 876 | 902 | 242 | 88 |
| California Teachers Study (CTS) | USA | 71 | 68 | 0 | 17 |
| ESTHER Breast Cancer Study (ESTHER) | Germany | 502 | 478 | 304 | 98 |
| Gene Environment Interaction and Breast Cancer in Germany (GENICA) | Germany | 427 | 465 | 328 | 119 |
| Helsinki Breast Cancer Study (HEBCS) | Finland | 1234 | 1664 | 1295 | 237 |
| Hannover-Minsk Breast Cancer Study (HMBCS) | Belarus | 130 | 690 | 37 | 0 |
| Karolinska Breast Cancer Study (KARBAC) | Sweden | 662 | 722 | 338 | 63 |
| Kuopio Breast Cancer Project (KBCP) | Finland | 251 | 445 | 304 | 97 |
| kConFab/Australian Ovarian Cancer Study (kConFab/AOCS) | Australia | 897 | 613 | 162 | 59 |
| Leuven Multidisciplinary Breast Centre (LMBC) | Belgium | 1388 | 2671 | 2071 | 379 |
| Mammary Carcinoma Risk Factor Investigation (MARIE) | Germany | 1778 | 1818 | 1349 | 399 |
| Milan Breast Cancer Study Group (MBCSG) | Italy | 400 | 488 | 149 | 42 |
| Mayo Clinic Breast Cancer Study (MCBCS) | USA | 1931 | 1862 | 1486 | 295 |
| Melbourne Collaborative Cohort Study (MCCS) | Australia | 511 | 614 | 352 | 119 |
| Multi-ethnic Cohort (MEC) | USA | 741 | 731 | 415 | 87 |
| Montreal Gene-Environment Breast Cancer Study (MTLGEBCS) | Canada | 436 | 489 | 421 | 64 |
| Norwegian Breast Cancer Study (NBCS) | Norway | 70 | 22 | 0 | 22 |
| Oulu Breast Cancer Study (OBCS) | Finland | 414 | 507 | 407 | 100 |
| Ontario Familial Breast Cancer Registryb (OFBCR) | Canada | 511 | 1175 | 630 | 268 |
| Leiden University Medical Centre Breast Cancer Study (ORIGO) | Netherlands | 327 | 357 | 211 | 70 |
| NCI Polish Breast Cancer Study (PBCS) | Poland | 424 | 519 | 519 | 0 |
| Karolinska Mammography Project for Risk Prediction of Breast Cancer (pKARMA) | Sweden | 5,537 | 5434 | 3672 | 702 |
| Rotterdam Breast Cancer Study (RBCS) | Netherlands | 699 | 664 | 368 | 131 |
| Singapore and Sweden Breast Cancer Study (SASBAC) | Sweden | 1378 | 1163 | 663 | 144 |
| Sheffield Breast Cancer Study (SBCS) | UK | 848 | 843 | 377 | 105 |
| Study of Epidemiology and Risk factors in Cancer Heredity (SEARCH) | UK | 8069 | 9347 | 5160 | 1181 |
| Städtisches Klinikum Karlsruhe Deutsches Krebsforschungszentrum Study (SKKDKFZS) | Germany | 29 | 136 | 0 | 136 |
| Szczecin Breast Cancer Study (SZBCS) | Poland | 315 | 365 | 165 | 60 |
| Triple Negative Breast Cancer Consortium Study (TNBCC) | Various | 542 | 881 | 0 | 881 |
| UK Breakthrough Generations Study (UKBGS) | UK | 470 | 476 | 96 | 22 |
| Asian women | |||||
| Asian Cancer Project (ACP) | Thailand | 636 | 423 | 92 | 53 |
| Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC) | Japan | 1376 | 694 | 395 | 139 |
| Los Angeles County Asian-American Breast Cancer Case-Control (LAABC) | USA | 990 | 812 | 528 | 138 |
| Malaysian Breast Cancer Genetic Study (MYBRCA) | Malaysia | 610 | 770 | 422 | 291 |
| Shanghai Breast Cancer Genetic Study (SBCGS) | China | 892 | 848 | 510 | 276 |
| Seoul Breast Cancer Study (SEBCS) | South Korea | 1129 | 1162 | 657 | 375 |
| Singapore Breast Cancer Cohort (SGBCC) | Singapore | 502 | 533 | 272 | 108 |
| IARC-Thai Breast Cancer (TBCS) | Thailand | 253 | 138 | 26 | 26 |
| Taiwanese Breast Cancer Study (TWBCS) | Taiwan | 236 | 889 | 460 | 204 |
| African-American women | |||||
| Southern Community Cohort Study (SCCS) | USA | 680 | 679 | 0 | 0 |
| Nashville Breast Health Study (NBHS) | USA | 252 | 437 | 199 | 222 |
| Total | 50 156 | 53 835 | 30 635 | 9120 | |
BCAC, Breast Cancer Association Consortium; COGS, Collaborative Oncological Gene-Environment Study; ER+, estrogen receptor-positive cases; ER−, estrogen receptor-negative cases.
aAustralian site of the Breast Cancer Family Registry.
bOntario site of the Breast Cancer Family Registry.