Table 3.
AKAP9-M463I (rs6964587) and risk of breast cancer based on published and new BCAC data
| Group/genotype | Controls, N (%) | Cases, N (%) | ORa (95% CI) | P-value |
|---|---|---|---|---|
| European women | ||||
| Published data (21 studies) | ||||
| GG | 12 650 (38) | 8952 (37) | 1.00 | |
| GT | 15 785 (47) | 11 400 (47) | 1.01 (0.97–1.05) | 0.58 |
| TT | 4941 (15) | 3802 (16) | 1.09 (1.03–1.15) | 0.0022 |
| Per T-allele | 1.04 (1.01–1.06) | 0.0058 | ||
| New COGS data (40 studiesb) | ||||
| GG | 11 044 (38) | 11 206 (36) | 1.00 | |
| GT | 13 858 (47) | 14 956 (48) | 1.06 (1.02–1.10) | 0.0031 |
| TT | 4390 (15) | 5129 (16) | 1.13 (1.07–1.19) | 1.6 × 10−6 |
| Per T-allele | 1.06 (1.04–1.09) | 9.2 × 10−7 | ||
| Asian women | ||||
| Published data (two studies) | ||||
| GG | 1514 (69) | 1746 (67) | 1.00 | |
| GT | 615 (28) | 763 (29) | 1.06 (0.93–1.20) | 0.58 |
| TT | 63 (2.9) | 86 (3.3) | 1.16 (0.83–1.62) | 0.42 |
| Per T-allele | 1.07 (0.96–1.19) | 0.37 | ||
| New COGS data (nine studiesc) | ||||
| GG | 4209 (65) | 3716 (65) | 1.00 | |
| GT | 2012 (31) | 1764 (31) | 1.02 (0.94–1.11) | 0.58 |
| TT | 241 (3.7) | 199 (3.5) | 1.03 (0.84–1.26) | 0.79 |
| Per T-allele | 1.02 (0.95–1.09) | 0.57 | ||
| African-American women | ||||
| New COGS data (two studies) | ||||
| GG | 213 (23) | 299 (27) | 1.00 | |
| GT | 480 (52) | 531 (48) | 0.80 (0.64–0.99) | 0.04 |
| TT | 236 (25) | 285 (26) | 0.89 (0.70–1.15) | 0.38 |
| Per T-allele | 0.95 (0.84–1.07) | 0.39 | ||
BCAC, Breast Cancer Association Consortium; OR, odds ratio; CI, confidence interval.
aOR estimated by logistic regression, adjusted for study (published data); adjusted for study and principal components (new data).
bNineteen studies of European women contributed both published data and new data.
cTwo studies of Asian women contributed both published data and new data.