Table 4.
ATXN7-K264R (rs1053338) and risk of breast cancer based on BCAC data
| Group/genotype | Controls, N (%) | Cases, N (%) | ORa (95% CI) | P |
|---|---|---|---|---|
| European women | ||||
| GG | 32 062 (75) | 34 467 (74) | 1.00 | |
| GT | 9764 (23) | 11 056 (24) | 1.07 (1.03–1.10) | 5.6 × 10−5 |
| TT | 773 (1.8) | 925 (2.0) | 1.14 (1.04–1.26) | 0.0073 |
| Per T-allele | 1.07 (1.04–1.10) | 2.9 × 10−6 | ||
| Asian women | ||||
| GG | 4978 (75) | 4600 (73) | 1.00 | |
| GT | 1534 (23) | 1536 (25) | 1.03 (0.94–1.12) | 0.55 |
| TT | 112 (1.7) | 132 (2.1) | 1.07 (0.82–1.39) | 0.63 |
| Per T-allele | 1.03 (0.96–1.11) | 0.46 | ||
| African-American women | ||||
| GG | 873 (94) | 1045 (94) | 1.00 | |
| GT | 59 (6.3) | 70 (6.3) | 0.95 (0.66–1.37) | 0.80 |
| TT | 0 (0) | 1 (0.0) | – | – |
| Per T-allele | 0.97 (0.68–1.40) | 0.89 | ||
COGS, Collaborative Oncological Gene-Environment Study; OR, odds ratio; CI, confidence interval.
aOR estimated by logistic regression, adjusted for study and principal components.