Table 2. Circadian parameters of Per2 promoter activities based on four days of data.
| period | amplitude | acrophase | P value | ||
| Caki-2 | control | 24.18±0.025 | 191.16±5.11 | 5.18±0.06 | <0.0001 |
| +HIF1α/ARNT | 24.18±0.025 | 325.97±2.91** | 5.33±0.04 | <0.0001 | |
| NIH3T3 | control | 24.43±0.05 | 7930.86±442.12 | 2.90±0.05 | <0.000001 |
| +HIF1α/ARNT | 24.23±0.08 | 41876.88±33.40** | 3.11±0.07 | <0.000001 | |
| U2OS | control | 23.83±0.13 | 220.63±31.95 | 7.52±0.76 | <0.000001 |
| +HIF1α/ARNT | 24.05±0.02 | 1121.36±58.72** | 6.02±0.09 | <0.000001 |
Period, amplitude, and acrophase of the oscillations were measured on days 2 to 5 using the Cosinor software (Circadian Rhythm Laboratory). Amplitude significantly increased (mean ± SEM, n = 4) compared to the control (** p<0.01, Student's t-test).