Table 2. Adjusted hazard ratios from cause-specific survival analyses for incident screen-detected cancers and for interval cancer (overall and subtypes).

	Incident SDC	IC	TI	FN	MS	OT
	HR* (95%CI)	HR* (95%CI)	HR* (95%CI)	HR* (95%CI)	HR* (95%CI)	HR* (95%CI)
Reading Method
Double	Ref	Ref	Ref	Ref	Ref	Ref
Single	1.31 (0.85–2.02)	0.85 (0.60–1.21)	1.55 (0.66–3.62)	1.09 (0.36–3.25)	1.38 (0.26–7.28)	0.52 (0.15–1.81)
Type of mammogram
SFM	Ref	Ref	Ref	Ref	Ref	Ref
DM	1.34 (1.12–1.61)	1.00 (0.78–1.28)	2.17 (1.37–3.45)	1.57 (0.78–3.13)	0.97 (0.35–2.67)	0.36 (0.11–1.24)
Early Recall
No	Ref	Ref	Ref	Ref	Ref	+
Yes	3.59 (3.12–4.14)	0.56 (0.40–0.78)	0.46 (0.22–0.96)	0.36 (0.15-0.83)	0.85 (0.29–2.46)
Previous false-positive
No	Ref	Ref	Ref	Ref	Ref	Ref
Yes	1.34 (1.20–1.60)	2.71 (2.28–3.23)	2.26 (1.59–3.21)	8.79 (6.24–12.40)	1.80 (0.93–3.47)	0.34 (0.08–1.39)
HRT use
No	Ref	Ref	Ref	Ref	Ref	Ref
Yes	0.98 (0.86–1.11)	1.27 (1.07–1.50)	1.33 (0.99–1.79)	1.30 (0.82–2.05)	1.63 (1.03–2.56)	0.92 (0.46–1.84)
Menopausal status
Postmenopausal	Ref	Ref	Ref	Ref	Ref	Ref
Premenopausal	1.26 (1.09–1.45)	1.41 (1.20–1.67)	1.29 (0.94–1.76)	1.28 (0.79–2.07)	0.91 (0.52–1.61)	1.33 (0.78–2.27)
Family history of breast cancer
No	Ref	Ref	Ref	Ref	Ref	Ref
Yes	1.75 (1.56–1.94)	1.65 (1.41–1.93)	2.11 (1.60–2.78)	1.44 (0.91–2.27)	1.67 (1.02–2.74)	1.44 (0.77–2.69)
Previous benign biopsy outside screening
No	Ref	Ref	Ref	Ref	Ref	Ref
Yes	1.34 (1.18–1.53)	1.73 (1.46–2.04)	1.26 (0.90–1.74)	1.83 (1.23–2.71)	1.44 (0.87–2.37)	1.12 (0.54–2.33)

*Multivariate Cox time-dependent models. The hazard ratios for each variable were adjusted for the other variables in the table, the year of the last mammogram, and for radiology unit (as a random effect).

+We excluded early recall, because there were no cases of early recall in occult tumors.

Abbreviations: SDC: Screen-detected cancer, IC: Interval Cancer, TI: True interval, FN: False-negative, MS: Minimal-signs, OT: Occult tumors, SFM: Screen-film mammography, DM: Digital mammography and HRT: Hormonal Replacement Therapy.