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Inhibition of TTR aggregation and fibril formation by SOM0226. WT TTR (a) and V122I TTR (b) at 4 μM were incubated at pH 4.4 for 3 days in the absence (DMSO, vehicle) or presence of SOM0226 (4 and 8 μM). Aggregation was measured by quantification of precipitated protein (insoluble) and normalized to total soluble protein at time 0. Percentage of fibril formation inhibition by SOM0226 is shown on the figure. Statistical significance was calculated by Student’s t test: **** p < 0.0001.
