Table 3. Subunit Exchange Kinetic Analysis between WT and FT2·WT TTR and between V122I and FT2·V122I TTRa.
FT2-homotetramer disappearanceb | nontagged TTR disappearanceb | 2 FT2/2 TTR (heterotetramer) formationb | |
---|---|---|---|
WT/FT2·WT TTR | 6.49 ± 0.42 | 10.21 ± 3.46 | 12.54 ± 4.71 |
V122I/FT2·V122I TTR | 1.92 ± 0.14 | 2.28 ± 0.37 | 2.84 ± 0.62 |
Calculated half-time (t50, h) for the disappearance of the homotetramers FT2 and untagged homotetramers and the appearance of the heterotetramer composed of 2 FT2 subunits and 2 untagged subunits.