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Velcro-like working mechanism of NanoVelcro cell-affinity substrates. (a) An anti-EpCAM-coated SiNS was employed to achieve significantly enhanced capture of CTCs in contrast to (b) an anti-EpCAM-coated flat silicon substrate. (c) Anti-EpCAM is grafted onto a SiNS to confer specificity for recognizing CTCs. (d, e) SEM images of a SiNS and a flat Si substrate, on which MCF7 cells were captured.
