Table 2. Segment definition for human TRPV1-4 channels based on UNIPROT details^*.

Segment	hTRPV1	hTRPV2	hTRPV3	hTRPV4
Nterm	1–110	1–71	1–116	1–147
Ank1 *	111–153	72–114	117–166	148–189
Ank2 *	154–200	115–161	167–213	190–236
Ank3 *	201–247	162–207	214–260	237–282
Ank4 *	248–283	208–243	261–295	283–319
Ank5 *	284–332	244–292	296–338	320–367
Ank6 *	333–359	293–319	339–366	368–395
MPD	360–433	320–390	367–439	396–465
TM1	434–454	391–411	440–460	466–486
loop1	455–476	412–434	461–487	487–508
TM2	477–497	435–455	488–508	509–529
loop2	498–513	456–471	509–523	530–550
TM3	514–534	472–492	524–544	551–571
loop3	535	493	545	572
TM4	536–556	494–514	546–566	573–593
loop4	557–579	515–537	567–589	594–616
TM5	580–600	538–558	590–610	617–637
loop5	601–635	559–595	611–621	638–662
pore	636–647	596–609	622–641	663–682
loop6	648–659	610–621	642–649	683–690
TM6	660–680	622–642	650–670	691–711
C-loop	681–696	643–654	671–690	712–731
TRPbox	697–702	659–664	691–697	732–738
Cam BS	768–802	655–686		812–831
PIP2	778–793
Cterm	803–839	687–764	698–790	832–871
Total length	839	764	790	871

*Ankyrin repeats were defined according to the crystal structure.