Figure 4. Esophageal lesions with signs of nonerosive microscopic esophagitis induced by water-immersion stress after 28 days of consumption of fructose-supplemented drinking water.

Panel A: Pretreatment with an inhibitor of cystathionine γ-lyase (L-propargylglycine; PAG) resulted in extensive esophageal inflammation, with profound submucosal leukocyte infiltration. Panel B: Macroscopic appearance of the lower esophagus of rat treated with PAG, with extensive perivascular hemorrhage. Panel C: Macroscopic appearance of lower esophagus of rat treated with PAG and L-tryptophan, the latter providing a protection against the detrimental effects of PAG.