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. 2013 Oct 28;1:109–125. doi: 10.1016/j.mgene.2013.09.009

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© 2013 The Authors. Published by Elsevier B.V. All rights reserved.

This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Fig. 2 — Forest plot of meta-analysis of association between maternal MTHFR C677T polymorphism and CHD risk and funnel plot analysis on the detection of publication bias. (A) Meta-analysis in a random effects model for C vs. T (additive model); (B) meta-analysis in a random effects model for CC vs. TT (co-dominant model); (C) meta-analysis in a random effects model for TT + CT vs. CC (dominant model); (D) meta-analysis in a random effects model for TT vs. CC + CT (recessive model). Left panel: forest plot analysis, each study is shown by the point of estimating the OR and 95% CIs for corresponding ORs were shown by extending lines; right panel: funnel plot analysis, each point represents an individual study. LogOR, natural logarithm of OR, perpendicular line denotes the mean effect size.