Table 2.
Genotype and allele distributions of maternal MTHFR C677T/A1298C polymorphisms in case-control studies included.
| Study | Sample size case/control | Genotype distribution |
Allele distribution |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Case |
Control |
A (case/control) | B (case/control) | ||||||||
| AA | AB | BB | AB + BB | AA | AB | BB | AB + BB | ||||
| MTHFR 677CT polymorphism | CC | CT | TT | CT + TT | CT | TT | CT + TT | C | T | CC | |
| Balderrabano-Saucedo | 31/62 | 7 (22.6%) | 12 (38.7%) | 12 (38.7%) | 24 (77.4%) | 24 (38.7%) | 31 (50%) | 7 (11.3%) | 38 (61.3%) | 26/79 | 36/45 |
| Božovic | 52/55 | 26 (50%) | 20 (38%) | 6 (12%) | 26 (50%) | 19 (35%) | 28 (51%) | 8 (14%) | 36 (65%) | 72/66 | 32/44 |
| Hobbs | 572/363 | 285 (51.5%) | 203 (36.7%) | 65 (11.8%) | 268 (48.5%) | 191 (53.7%) | 128 (36%) | 37 (10.4%) | 165 (46.4%) | 773/510 | 333/202 |
| García-Fragoso | 27/220 | 10 (37%) | 11 (41%) | 6 (22%) | 17 (63%) | 84 (38%) | 115 (52%) | 21 (10%) | 136 (62%) | 31/283 | 23/157 |
| van Driel | 230/251 | 91 (40%) | 117 (51%) | 22 (9%) | 139 (60%) | 111 (44%) | 104 (42%) | 36 (14%) | 140 (56%) | 299/326 | 161/176 |
| Wintner | 31/31 | 17 (54.84%) | 11 (35.48%) | 3 (9.68%) | 14 (45.16%) | 10 (32.26%) | 17 (54.84%) | 4 (12.9%) | 21 (67.74%) | 45/37 | 17/25 |
| Van Beynum | 158/261 | 72 (45.6%) | 68 (43%) | 18 (11.4%) | 86 (54.4%) | 131 (50.2%) | 107 (41%) | 23 (8.8%) | 130 (49.8%) | 212/369 | 104/153 |
| Galdieri | 47/26 | 27 (57.45%) | 15 (31.91%) | 5 (10.64%) | 20 (42.55%) | 10 (38.46%) | 15 (57.70%) | 1(3.84%) | 16 (61.54) | 69/17 | 25/17 |
| Zhu | 56/102 | 6 (10.71%) | 27 (48.21%) | 23 (41.08%) | 50 (89.29%) | 20 (19.61) | 57 (55.88%) | 25 (24.51%) | 82 (80.39%) | 39/97 | 73/107 |
| Storti | 103/200 | 27 (26%) | 53 (52%) | 23 (22%) | 76 (74%) | 52 (26%) | 108 (54%) | 40 (20%) | 148 (74%) | 107/212 | 99/188 |
| Sanchez-Urbina | 60/62 | 8 (13.3%) | 38 (63.3%) | 14 (23.3%) | 52 (86.6%) | 13 (21%) | 37 (59.7%) | 12 (19.3%) | 49 (79%) | 54/63 | 66/61 |
| Wang | 104/208 | 25 (24.04%) | 60 (57.69%) | 19 (18.27%) | 79 (76.39%) | 49 (23.56%) | 120 (57.69%) | 39 (18.75%) | 159 (76.44%) | 110/218 | 98/198 |
| Li | 183/102 | 32 (17.49%) | 90 (49.18%) | 61 (33.33%) | 151 (82.51%) | 20 (19.61%) | 57 (55.88%) | 25 (24.51%) | 82 (80.39%) | 154/97 | 212/107 |
| Peng | 91/101 | 32 (35.2%) | 48 (52.7%) | 11 (12.1%) | 59 (64.8%) | 46 (45.5%) | 44 (43.6%) | 11 (10.9%) | 55 (54.5%) | 112/136 | 70/66 |
| MTHFR 1298AC polymorphism | AA | AC | CC | AC + CC | AA | AC | CC | AC + CC | A | C | |
| Božovic | 52/55 | 21 (40%) | 27 (52%) | 4 (8%) | 31 (60%) | 27 (49%) | 27 (49%) | 1 (2%) | 28 (51%) | 69/81 | 35/29 |
| van Driel | 230/251 | 104 (45%) | 102 (45%) | 24 (10%) | 126 (55%) | 116 (46%) | 104 (42%) | 31 (12%) | 135 (54%) | 310/336 | 150/166 |
| Galdieri | 47/26 | 26 (55.32%) | 17 (36.17%) | 4 (8.51%) | 21 (44.68%) | 15 (57.7%) | 10 (38.46%) | 1 (3.84%) | 11 (42.3%) | 69/25 | 25/12 |
| Storti | 103/200 | 49 (48%) | 46 (45%) | 8 (7%) | 54 (52%) | 101 (50%) | 86 (43%) | 13 (7%) | 99 (50%) | 144/288 | 62/112 |