. 2013 Oct 28;1:109–125. doi: 10.1016/j.mgene.2013.09.009

Table 6.

Pooled ORs and 95% CIs of the association between maternal/fetal MTHFR A1298C polymorphism and CHD.

Contrasts	No. of studies	Total case/control	C vs. A			CC vs. AA			CC + AC vs. AA			CC vs. AC + AA
Contrasts	No. of studies	Total case/control	OR	95% CI	P_H	OR	95% CI	P_H	OR	95% CI	P_H	OR	95% CI	P_H
Maternal
All studies	4	432/532	1.043	0.855–1.271	0.585	1.109	0.692–1.775	0.405	1.108	0.856–1.435	0.912	0.735	0.467–1.157	0.053
All types of CHD	3	329/332	1.018	0.805–1.287	0.407	1.062	0.617–1.825	0.250	1.102	0.810–1.499	0.769	0.615	0.366–1.034	0.063
CD	1	103/200	1.107	0.765–1.601	–	1.268	0.493–3.262	–	1.124	0.699–1.809	–	1.276	0.512–3.183	–
HB	2	150/226	1.040	0.741–1.458	0.407	1.405	0.594–3.323	0.634	1.120	0.731–1.716	0.970	1.412	0.613–3.253	0.627
PB	2	282/306	1.044	0.818–1.344	0.263	1.003	0.572–1.761	0.134	1.102	0.796–1.524	0.468	0.557	0.324–0.957	0.048
Small	2	99/81	1.150	0.712–1.856	0.224	3.476	0.700–17.271	0.625	1.289	0.708–2.350	0.684	3.266	0.674–15.825	0.682
Large	2	333/451	1.022	0.822–1.270	0.599	0.961	0.581–1.591	0.500	1.071	0.804–1.426	0.800	0.608	0.372–0.993	0.059

Fetal
All studies	5	945/1074	0.938	0.812–1.083	0.171	1.058	0.719–1.558	0.331	0.871	0.728–1.042	0.128	1.184	0.815–1.721	0.516
All types of CHD	4	842/874	0.884	0.756–1.034	0.422	0.924	0.600–1.421	0.460	0.813	0.670–0.987	0.281	1.085	0.715–1.646	0.496
CD	1	103/200	1.295	0.901–1.861	–	1.899	0.791–4.562	–	1.315	0.815–2.121	–	1.720	0.742–3.987	–
HB	3	662/765	1.017	0.851–1.216	0.145	1.221	0.725–2.057	0.168	0.991	0.799–1.229	0.275	1.216	0.729–2.027	0.233
PB	2	283/309	0.805	0.630–1.028	0.627	0.889	0.499–1.582	0.603	0.648	0.467–0.898	0.846	1.149	0.664–1.989	0.582
Small	2	111/96	0.667	0.428–1.041	0.781	0.351	0.084–1.460	0.461	0.616	0.354–1.073	0.949	0.427	0.105–1.730	0.416
Large	3	834/978	0.976	0.838–1.136	0.150	1.166	0.778–1.749	0.429	0.907	0.750–1.096	0.064	1.293	0.875–1.912	0.758
Caucasian	4	443/547	0.902	0.743–1.095	0.108	1.014	0.636–1.618	0.209	0.793	0.615–1.023	0.106	1.183	0.757–1.848	0.353
Asian	1	502/527	0.984	0.794–1.219	–	1.161	0.582–2.316	–	0.955	0.742–1.229	–	1.188	0.599–2.356	–

Abbreviations: OR, odds ratio; CI, confidence interval; P_H, p value based on Q test for between-study heterogeneity; HWE, Hardy–Weinberg equilibrium; CD, conotruncal heart defects; PB, population-based; HB, hospital-based.