Table 2.
Association of Lower Extremity Function and Midlife PA Among Dementia Free Population
| Adjusted mean differences of lower extremity function scores by mid-life PA levels | ||||
|---|---|---|---|---|
| Population (n=4753) | Active Group (n=1478) versus Inactive Group (n= 3275) | |||
|
| ||||
| Lower Extremity Function | β coefficient (95% Confidence Interval ) | P-value | ||
| Model 1 | 0.055* | (0.044 ~ 0.066) | <.0001 | |
| Gait Speed | Model 2 | 0.053* | (0.042 ~ 0.064) | <.0001 |
| Model 3 | 0.053* | (0.042 ~ 0.064) | <.0001 | |
| Model 4 | 0.049* | (0.038 ~ 0.059) | <.0001 | |
| Model 1 | −0.62* | (−0.80 ~ −0.44) | <.0001 | |
| Timed Up and Go | Model 2 | −0.59* | (−0.77 ~ −0.41) | <.0001 |
| Model 3 | −0.59* | (−0.77 ~ −0.41) | <.0001 | |
| Model 4 | −0.53* | (−0.71 ~ −0.36) | <.0001 | |
| Model 1 | 1.50* | (0.98 ~ 2.02) | <.0001 | |
| Knee Extension | Model 2 | 1.51* | (0.99 ~ 2.03) | <.0001 |
| Model 3 | 1.50* | (0.98 ~ 2.02) | <.0001 | |
| Model 4 | 1.34* | (0.83 ~ 1.86) | <.0001 | |
Model 1 = adjusted for age, sex and education
Model 2 = + midlife covariates: BMI, systolic blood pressure, cholesterol, and smoking
Model 3 = + late-life covariates: diabetes, coronary event, high depressive symptoms, smoking, and self reported stroke
Model 4 = + MMSE score
Abbreviations: PA, physical activity; MMSE, mini mental state examination