Table 3:
Comparison of clinical parameters, immunological markers, World Health Organization clinical stage and immunological stage for human immunodeficiency virus-1-infected children at diagnosis and following six months of highly active antiretroviral therapy and treatment for opportunistic infections (N = 20)
| At diagnosis* | After therapy | P value | |
|---|---|---|---|
| Clinical parameter | |||
| Mean Hb in g % | 7.78 ± 2.36 | 9.28 ± 1.13 | <0.05 |
| Mean weight in kg | 13.95 ± 7.63 | 18.8 ± 7.32 | <0.01 |
| Mean height in cm | 105.72 ± 27.06 | 110 ± 25.66 | <0.01 |
| Immunological marker | |||
| Mean total lymphocyte count in mm3 | 3,061 ± 1,723 | 2,931 ± 1,169 | >0.05 |
| Mean CD4 count in cells/mm3 | 391 ± 274 | 720 ± 356 | <0.01 |
| Mean CD4 percentage | 12.86 ± 7.54 | 25.53 ± 15.03 | <0.01 |
| Clinical stage10 | |||
| 1 | 0 | 0 | <0.05 |
| 2 | 1 | 17 | |
| 3 | 12 | 1 | |
| 4 | 7 | 2 | |
| Immunological stage8 | |||
| Not significant | 2 | 10 | <0.05 |
| Mild | 1 | 6 | |
| Advanced | 8 | 3 | |
| Severe | 9 | 1 | |
Hb = haemoglobin; CD4 = cluster of differentiation 4.
*
Upon diagnosis of an opportunistic infection.