Table 1. Genes with rare heterozygous non-synonymous or splicing variants identified by exome sequencing in both partners of eight non-consanguineous couples of European ancestry.

Couple	Number of genes with a different heterozygous variant	Genes	Number of genes with the same heterozygous variant	Genes
1	2	SPTBN4, ALDOB	2	LY6G5C, SYNPO2
2	3	C5orf42, SUPT20H, ZFHX3	0
3	0		1	LENG8
4	0		1	CUL7
5	0		0
6	0		2	KCNMA1, PRR12
7	0		0
8	3	HSPG2, MUC16, ZNF469	0
Mean	1.0		0.75