Table 2. Genes with rare heterozygous non-synonymous or splicing variants identified by exome sequencing in three couples with multiple fetuses affected with a presumed autosomal recessive lethal condition.

Family	Number of genes with a different heterozygous variant in each parent	Genes	Number of genes with the same heterozygous variant in each parent
Short-rib polydactyl	2	DYNC2H1, NR1D1	0
1	2	CLIP1, GLE1	0
2	4	CC2D1, FAM129C, OBSCN, RYR1	0

Genes shown in bold are those in which compound heterozygous variants were identified in the affected fetuses.