. Author manuscript; available in PMC: 2014 Oct 21.

Published in final edited form as: Biochem J. 2014 Sep 15;462(3):397–413. doi: 10.1042/BJ20140400

Table 1. Zinc finger ATF libraries used in mammalian cells.

Phenotype or reporter gene screened	Library complexity	Number of zinc fingers	Target enrichment	Effector domain	Number of hits validated	Reference
γ-Globulin	1.7×10⁷	5	GNN (16), ANN (15), CNN (15)	VP64 or KRAB	4	[165]
CD58, CDH5, EGF, FUT4, ICAM1, ERBB2, ERBB3, ITGA6, ITGB4 and TNFRSF6	1.0×10⁴ and 8.4×10⁷	3 and 6	GNN (16), ANN (4), TNN (3)	VP64	4 for CDH5	[68]
ICAM-1	8.4×10⁷	6	GNN (16), ANN (4), TNN (3)	VP64	4	[163]
Taxol resistance	8.4×10⁷	6	GNN (16), ANN (4), TNN (3)	VP64	1	[172]
Drug resistance	1.0×10⁴ and 8.4×10⁷	3 and 6	GNN (16), ANN (4), TNN (3)	VP64	3	[174]
VEGF	1.5×10²	3	GNN (28), ANN (4), other (4)	p65 or VP16	4	[60]
Neuronal morphology, ALP	2.4×10⁵	4	GNN (37), ANN (9), TNN (2), other (7)	p65 or KRAB	2	[170]
Taxol resistance	Not described	4	25 from [60]	p65	2	[171]
SEAP	2.4×10⁵	3 and 4	GNN (37), ANN (9), TNN (2), other (7)	p65 or KRAB	3	[222]
Production of antibodies against TAG72	2.4×10⁵	4	GNN (37), ANN (9), TNN (2), other (7)	VP16 or KRAB	4	[173]
Fulvestrant resistance	4.0×10⁵	4	GNN (14), ANN (15), CNN (15)	p65	6	[221]