Table 2.

Topical RPM Inhibited PDL-induced mRNA Levels of Some Examples of Angiogenic Genes

Day	P value	FGF16	PDGFb	HGF	VEGFa	HIF1a	TEK	EPAS1	TGFb3
1	F	7.952	19.147	6.371	1.178	10.759	24.339	6.919	5.115
	P	0.021	0.002	0.033	0.370	0.010	0.001	0.028	0.051
	P1	0.026	0.003	0.025	N.A.	0.019	0.000	0.047	N.A.
	P2	0.076	0.019	0.790	N.A.	0.068	0.059	0.066	N.A.
3	F	0.449	227.458	5.197	20.783	5.667	26.554	3.531	49.670
	P	0.658	0.000	0.049	0.002	0.041	0.001	0.097	0.000
	P1	N.A.	0.000	0.065	0.009	0.069	0.006	N.A.	0.004
	P2	N.A.	0.000	0.127	0.010	0.083	0.006	N.A.	0.001
5	F	416.923	480.432	35.208	268.954	845.395	0.333	333.033	1727.746
	P	0.000	0.000	0.000	0.000	0.000	0.729	0.000	0.000
	P1	0.000	0.000	0.000	0.000	0.000	N.A.	0.000	0.000
	P2	0.000	0.000	0.004	0.001	0.000	N.A.	0.115	0.000
7	F	16.304	7.480	14.004	12.931	25.968	2.306	6.841	7.357
	P	0.004	0.023	0.005	0.007	0.001	0.181	0.028	0.024
	P1	0.000	0.036	0.007	0.001	0.001	N.A.	0.034	0.136
	P2	0.000	0.070	0.026	0.034	0.009	N.A.	0.081	0.153
10	F	1.435	5.732	2.260	0.249	0.396	1.072	1.364	1.957
	P	0.309	0.041	0.186	0.787	0.689	0.400	0.325	0.222
	P1	N.A.	0.123	N.A.	N.A.	N.A.	N.A.	N.A.	N.A.
	P2	N.A.	0.055	N.A.	N.A.	N.A.	N.A.	N.A.	N.A.
14	F	0.684	2.862	1.128	1.025	16.724	15.129	4.718	47.110
	P	0.540	0.134	0.384	0.414	0.004	0.005	0.059	0.000
	P1	N.A.	N.A.	N.A.	N.A.	0.683	0.452	N.A.	0.264
	P2	N.A.	N.A.	N.A.	N.A.	0.013	0.021	N.A.	0.003

The fold changes of mRNA levels of each molecule are obtained by comparison to the control values which are set as 1. F and P are the values from ANOVA among the groups. Additional paired t-tests between the groups were performed only for those groups showing a statistical significance (p<0.05) by ANOVA. P1: Laser versus control; P2: Laser versus laser+RPM. N=3 or 4 animals for each treatment time point. N.A.: not available; p values from paired t-tests between two groups were not performed due to no statistical significance as determined by ANOVA.